Recognition of alpha-mannan by dectin 2 is essential for onset of Kawasaki disease-like murine vasculitis induced by Candida albicans cell-wall polysaccharide.
Mod Rheumatol
; 30(2): 350-357, 2020 Mar.
Article
em En
| MEDLINE
| ID: mdl-30924376
ABSTRACT
Objectives:
Using a murine model of systemic Kawasaki disease (KD)-like vasculitis induced by Candida albicans cell-wall-derived mannan · ß-glucan · protein complexes, the objective was to elucidate the relationships of ß-glucan receptor dectin-1 (D1) and α-mannan receptor dectin-2 (D2) to the onset of that vasculitis.Methods:
The incidence and histological severity of vasculitis were compared among mice lacking the genes for D1 or D2 (i.e. D1-/- and D2-/-) and wild-type (WT) mice.Results:
The incidences of vasculitis in the three animal groups were 100% (18/18) in the WT group, 100% (18/18) in the D1-/- group, and 0% (0/18) in the D2-/- group. In the WT and D1-/- mice, severe inflammatory cell infiltration, consisting mainly of neutrophils and macrophages, was seen in the aortic root and the coronary arteries. On the other hand, in the D2-/- mice, not even mild vascular lesions such as endoarteritis were seen.Conclusion:
Recognition of α-mannan by D2 played an important role in the onset of vasculitis in the studied murine model.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Vasculite
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Lectinas Tipo C
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Mananas
/
Síndrome de Linfonodos Mucocutâneos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article