Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review.
Mol Cancer
; 18(1): 63, 2019 03 30.
Article
em En
| MEDLINE
| ID: mdl-30927923
ABSTRACT
The tumor microenvironment (TME) is comprised of many different cell populations, such as cancer-associated fibroblasts and various infiltrating immune cells, and non-cell components of extracellular matrix. These crucial parts of the surrounding stroma can function as both positive and negative regulators of all hallmarks of cancer development, including evasion of apoptosis, induction of angiogenesis, deregulation of the energy metabolism, resistance to the immune detection and destruction, and activation of invasion and metastasis. This review represents a summary of recent studies focusing on describing these effects of microenvironment on initiation and progression of the head and neck squamous cell carcinoma, focusing on oral squamous cell carcinoma, since it is becoming clear that an investigation of differences in stromal composition of the head and neck squamous cell carcinoma microenvironment and their impact on cancer development and progression may help better understand the mechanisms behind different responses to therapy and help define possible targets for clinical intervention.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Escamosas
/
Microambiente Tumoral
/
Neoplasias de Cabeça e Pescoço
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article