Glucagon receptor antagonism increases mouse pancreatic Î´-cell mass through cell proliferation and duct-derived neogenesis.

Gu, Liangbiao; Cui, Xiaona; Lang, Shan; Wang, Haining; Hong, Tianpei; Wei, Rui

Gu, Liangbiao; Cui, Xiaona; Lang, Shan; Wang, Haining; Hong, Tianpei; Wei, Rui.

Afiliação

Gu L; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China; Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China.
Cui X; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China; Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China.
Lang S; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China; Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China.
Wang H; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China; Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China.
Hong T; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China; Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China.
Wei R; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China; Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China. Electronic address: weirui@bjmu.edu.cn.

Biochem Biophys Res Commun ; 512(4): 864-870, 2019 05 14.

Article em En | MEDLINE | ID: mdl-30929915

Assuntos

Anticorpos Monoclonais/farmacologia; Hipoglicemiantes/farmacologia; Receptores de Glucagon/antagonistas & inibidores; Células Secretoras de Somatostatina/metabolismo; Animais; Animais Recém-Nascidos; Proliferação de Células/efeitos dos fármacos; Forma Celular; Diabetes Mellitus Experimental/tratamento farmacológico; Diabetes Mellitus Experimental/metabolismo; Diabetes Mellitus Experimental/patologia; Diabetes Mellitus Tipo 1/tratamento farmacológico; Diabetes Mellitus Tipo 1/metabolismo; Diabetes Mellitus Tipo 1/patologia; Glucagon/sangue; Humanos; Insulina/sangue; Camundongos Endogâmicos C57BL; Somatostatina/sangue; Células Secretoras de Somatostatina/efeitos dos fármacos

Palavras-chave

Diabetes; Glucagon receptor antibody; Islet regeneration; Î´-cell

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Glucagon / Células Secretoras de Somatostatina / Hipoglicemiantes / Anticorpos Monoclonais Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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