BINOL-derived bifunctional sulfide catalysts for asymmetric synthesis of 3,3-disubstituted phthalides via bromolactonization.
Org Biomol Chem
; 17(15): 3747-3751, 2019 04 10.
Article
em En
| MEDLINE
| ID: mdl-30931456
ABSTRACT
An efficient enantioselective synthesis of 3,3-disubstituted phthalides possessing a chiral quaternary carbon center was achieved via catalytic asymmetric bromolactonization that utilized BINOL-derived bifunctional sulfide catalysts. Transformations of the bromo group in optically active phthalide products were also performed to demonstrate the utility of this novel synthetic protocol.
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MEDLINE
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En
Ano de publicação:
2019
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Article