Achiral amino acid glycine acts as an origin of homochirality in asymmetric autocatalysis.
Org Biomol Chem
; 17(17): 4200-4203, 2019 04 24.
Article
em En
| MEDLINE
| ID: mdl-30932119
ABSTRACT
Chiral crystals of the only achiral proteinogenic α-amino acid, glycine induced the asymmetric autocatalysis with amplification of enantiomeric excess (ee). The P31 crystals of γ-glycine, which display positive Cotton effect (CD) at around 215 nm, mediate the asymmetric autocatalysis to yield (R)-pyrimidyl alkanol with high ee. In contrast, the enantiomorphic P32 crystals, which display negative Cotton effect, afford (S)-alkanol after the significant amplification of ee by asymmetric autocatalysis.
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MEDLINE
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En
Ano de publicação:
2019
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Article