Urothelial carcinoma of the upper urinary tract: preoperative pyuria is not correlated with bladder cancer recurrence and survival.
Int Urol Nephrol
; 51(5): 831-838, 2019 May.
Article
em En
| MEDLINE
| ID: mdl-30937606
ABSTRACT
OBJECTIVE:
To identify the impact of preoperative pyuria on the bladder cancer recurrence and survival of patients who were treated surgically for UTUC. PATIENTS ANDMETHODS:
Study included 319 consecutive patients who were treated with RNU for UTUC. Cox proportional hazard regression models were used to evaluate the association of preoperative pyuria with outcome.RESULTS:
Eighty patients (25.1%) had pyuria. Preoperative pyuria was associated with sex (P = 0.01), tumor focality (P = 0.01), tumor size (P = 0.05), tumor stage (P = 0.01), lymph node metastasis (P = 0.01), lymphovascular invasion (P = 0.02), and chemotherapy (P = 0.04). A total of 102 patients recurred, with a median time to bladder recurrence of 24.2 months. Bladder cancer recurrence-free survival rates for these 319 patients at 1, 3, 5, 7, and 10 years were 84.6, 72.4, 69.0, 68.3, and 68.0%, respectively. Preoperative pyuria was not independently associated with bladder cancer recurrence (HR 1.15; p = 0.5). Preoperative pyuria was associated with OS (HR 1.57; p = 0.02) and CSS (HR 1.65; p = 0.02). However, preoperative pyuria was not independently associated with OS and CSS (HR 1.07; p = 0.79).CONCLUSIONS:
Preoperative pyuria is unable to predict outcomes in a single-centre series of consecutive patients who were treated with RNU.Palavras-chave
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Assunto principal:
Neoplasias Ureterais
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Neoplasias da Bexiga Urinária
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Carcinoma de Células de Transição
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Segunda Neoplasia Primária
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Neoplasias Renais
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Recidiva Local de Neoplasia
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article