miR-124a inhibits the proliferation and inflammation in rheumatoid arthritis fibroblast-like synoviocytes via targeting PIK3/NF-&#954;B pathway.

Yang, BiLing; Ge, Yan; Zhou, Yang; Wang, Jia; Xie, Xi; Li, Shu; Tang, Mengshi; Xu, LiChang; Tian, Jing

miR-124a inhibits the proliferation and inflammation in rheumatoid arthritis fibroblast-like synoviocytes via targeting PIK3/NF-κB pathway.

Yang, BiLing; Ge, Yan; Zhou, Yang; Wang, Jia; Xie, Xi; Li, Shu; Tang, Mengshi; Xu, LiChang; Tian, Jing.

Afiliação

Yang B; Department of Rheumatology and Immunology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Ge Y; Department of Rheumatology and Immunology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Zhou Y; Department of Rheumatology and Immunology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Wang J; Department of Rheumatology and Immunology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Xie X; Department of Rheumatology and Immunology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Li S; Department of Rheumatology and Immunology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Tang M; Department of Rheumatology and Immunology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Xu L; International Department of YALI High School, Changsha, Hunan, China.
Tian J; Department of Rheumatology and Immunology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.

Cell Biochem Funct ; 37(4): 208-215, 2019 Jun.

Article em En | MEDLINE | ID: mdl-30941802

Assuntos

Artrite Reumatoide/patologia; Fibroblastos; Inflamação/genética; MicroRNAs/genética; NF-kappa B/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Transdução de Sinais/genética; Sinoviócitos/metabolismo; Animais; Artrite Experimental/genética; Artrite Experimental/metabolismo; Artrite Experimental/patologia; Artrite Reumatoide/genética; Artrite Reumatoide/metabolismo; Proliferação de Células/genética; Colágeno; Humanos; Inflamação/metabolismo; Inflamação/patologia; Masculino; Camundongos; Camundongos Endogâmicos DBA; Sinoviócitos/patologia

Palavras-chave

NF-κB; PIK3/Akt; arthritis; inflammation; miR-124a; rheumatoid arthritis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Transdução de Sinais / NF-kappa B / Fosfatidilinositol 3-Quinases / MicroRNAs / Fibroblastos / Sinoviócitos / Inflamação Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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