Targeting SOCS Proteins to Control JAK-STAT Signalling in Disease.
Trends Pharmacol Sci
; 40(5): 298-308, 2019 05.
Article
em En
| MEDLINE
| ID: mdl-30948191
ABSTRACT
Defective regulation of the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signalling pathway in cancers, haematological diseases, and chronic inflammatory conditions highlights its clinical significance. While several biologic and small molecule therapeutics targeting this pathway have been developed, these have several limitations. Therefore, there is a need to identify new targets for intervention. Suppressor of cytokine signalling (SOCS) proteins are a family of inducible inhibitors of cytokine receptors that activate the JAK-STAT pathway. Here we propose that newly identified mechanisms controlling SOCS function could be exploited to develop molecularly targeted drugs with unique modes of action to inhibit JAK-STAT signalling in disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Fatores de Transcrição STAT
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Proteínas Supressoras da Sinalização de Citocina
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Janus Quinases
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article