Pulmonary Pharmacokinetics of Oseltamivir Carboxylate in Rats after Nebulization or Intravenous Administration of Its Prodrug, Oseltamivir Phosphate.
Antimicrob Agents Chemother
; 63(6)2019 06.
Article
em En
| MEDLINE
| ID: mdl-30962337
ABSTRACT
The aim of this study was to investigate the pharmacokinetics of oseltamivir phosphate, a prodrug, and its active moiety in plasma and lung after its nebulization and intravenous administration in rats. Only 2% of prodrug was converted into active moiety presystematically, attesting to a low advantage of oseltamivir phosphate nebulization, suggesting that oseltamivir phosphate nebulization is not a good option to obtain a high exposure of the active moiety at the infection site within lung.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pró-Fármacos
/
Oseltamivir
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article