Expression of Interleukin-6 and Integrin ανß6 in Colon Cancer: Association with Clinical Outcomes and Prognostic Implications.
Cancer Invest
; 37(3): 174-184, 2019.
Article
em En
| MEDLINE
| ID: mdl-30982362
ABSTRACT
As important factors in the tumor microenvironment, interleukin-6 (IL-6) and integrin ανß6 play significant roles in accumulating mutations that drive the progression and metastatic capacities of cancer. The aim of this study was to investigate the expression of IL-6 and integrin ανß6, their clinical significance, as well as their correlation in the colon cancer tissues of 145 cases using immunohistochemistry. Our results showed that IL-6 and integrin ανß6 are indicators of cancer progression and poor prognosis in patients with colon cancer. Moreover, their relationship may provide clues for further studies on how the tumor microenvironment mediates the development of colon cancer, as well as strategies for the identification of novel therapeutic targets in the prevention and treatment of colon cancer.
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Base de dados:
MEDLINE
Assunto principal:
Integrinas
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Interleucina-6
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Neoplasias do Colo
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Microambiente Tumoral
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Antígenos de Neoplasias
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article