Identification of a single-nucleotide polymorphism within <i>CDH2</i> gene associated with bone morbidity in childhood acute lymphoblastic leukemia survivors.

Aaron, Michelle; Nadeau, Geneviève; Ouimet-Grennan, Erika; Drouin, Simon; Bertout, Laurence; Beaulieu, Patrick; St-Onge, Pascal; Shalmiev, Albert; Veilleux, Louis-Nicolas; Rauch, Frank; Petrykey, Kateryna; Laverdière, Caroline; Sinnett, Daniel; Alos, Nathalie; Krajinovic, Maja

Identification of a single-nucleotide polymorphism within CDH2 gene associated with bone morbidity in childhood acute lymphoblastic leukemia survivors.

Aaron, Michelle; Nadeau, Geneviève; Ouimet-Grennan, Erika; Drouin, Simon; Bertout, Laurence; Beaulieu, Patrick; St-Onge, Pascal; Shalmiev, Albert; Veilleux, Louis-Nicolas; Rauch, Frank; Petrykey, Kateryna; Laverdière, Caroline; Sinnett, Daniel; Alos, Nathalie; Krajinovic, Maja.

Afiliação

Aaron M; Department of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada.
Nadeau G; Department of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada.
Ouimet-Grennan E; Department of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada.
Drouin S; Sainte-Justine University Hospital Research Centre, Montreal, Quebec, H3T 1C5, Canada.
Bertout L; Sainte-Justine University Hospital Research Centre, Montreal, Quebec, H3T 1C5, Canada.
Beaulieu P; Sainte-Justine University Hospital Research Centre, Montreal, Quebec, H3T 1C5, Canada.
St-Onge P; Sainte-Justine University Hospital Research Centre, Montreal, Quebec, H3T 1C5, Canada.
Shalmiev A; Department of Pharmacology and Physiology, Université de Montréal, Quebec, H3T 1J4, Canada.
Veilleux LN; Montreal Shriners Hospital for Children, Montreal, Quebec, H4A 0A9, Canada.
Rauch F; Montreal Shriners Hospital for Children, Montreal, Quebec, H4A 0A9, Canada.
Petrykey K; Sainte-Justine University Hospital Research Centre, Montreal, Quebec, H3T 1C5, Canada.
Laverdière C; Department of Pharmacology and Physiology, Université de Montréal, Quebec, H3T 1J4, Canada.
Sinnett D; Sainte-Justine University Hospital Research Centre, Montreal, Quebec, H3T 1C5, Canada.
Alos N; Department of Pediatrics, Université de Montréal, Quebec, H3T 1J4, Canada.
Krajinovic M; Sainte-Justine University Hospital Research Centre, Montreal, Quebec, H3T 1C5, Canada.

Pharmacogenomics ; 20(6): 409-420, 2019 04.

Article em En | MEDLINE | ID: mdl-30983502

Assuntos

Antígenos CD/genética; Caderinas/genética; Predisposição Genética para Doença/genética; Polimorfismo de Nucleotídeo Único/genética; Leucemia-Linfoma Linfoblástico de Células Precursoras/genética; Adolescente; Adulto; Alelos; Densidade Óssea/genética; Osso e Ossos/patologia; Criança; Feminino; Humanos; Masculino; Fatores de Risco; Sobreviventes; Sequenciamento do Exoma/métodos; Adulto Jovem

Palavras-chave

acute lymphoblastic leukemia; bone mineral density; genetic association study; genetic variants; late adverse effects; skeletal morbidities; survivorship; vertebral fractures; whole exome sequencing

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antígenos CD / Caderinas / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Leucemia-Linfoma Linfoblástico de Células Precursoras Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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