Protein Structure-Guided Hidden Markov Models (HMMs) as A Powerful Method in the Detection of Ancestral Endogenous Viral Elements.
Viruses
; 11(4)2019 04 02.
Article
em En
| MEDLINE
| ID: mdl-30986983
ABSTRACT
It has been believed for a long time that the transfer and fixation of genetic material from RNA viruses to eukaryote genomes is very unlikely. However, during the last decade, there have been several cases in which "virus-to-host" gene transfer from various viral families into various eukaryotic phyla have been described. These transfers have been identified by sequence similarity, which may disappear very quickly, especially in the case of RNA viruses. However, compared to sequences, protein structure is known to be more conserved. Applying protein structure-guided protein domain-specific Hidden Markov Models, we detected homologues of the Virgaviridae capsid protein in Schizophora flies. Further data analysis supported "virus-to-host" transfer into Schizophora ancestors as a single transfer event. This transfer was not identifiable by BLAST or by other methods we applied. Our data show that structure-guided Hidden Markov Models should be used to detect ancestral virus-to-host transfers.
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MEDLINE
Assunto principal:
Proteínas Virais
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Vírus
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Cadeias de Markov
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Eucariotos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article