Plasma endothelin-1 and adrenomedullin are associated with coronary artery function and cardiovascular outcomes in humans.
Int J Cardiol
; 291: 168-172, 2019 09 15.
Article
em En
| MEDLINE
| ID: mdl-30987836
ABSTRACT
BACKGROUND:
Endothelin-1 (ET-1) is a vasoconstrictor associated with cardiovascular disease, whereas adrenomedullin (ADM) is a vasorelaxant with cardioprotective properties. We sought to determine the relationship between plasma ET-1 and ADM with coronary circulatory function and long-term major adverse cardiovascular events (MACE).METHODS:
Thirty-two patients undergoing coronary angiography for chest pain were recruited. Baseline plasma ET-1 and ADM levels were measured. The index of microcirculatory resistance (IMR), coronary flow mediated dilatation (cFMD) and coronary flow reserve (CFR) were measured in a non-obstructed coronary artery. Patients were assessed for MACE over a median period of 8.8â¯years.RESULTS:
Plasma ET-1 levels correlated with IMR (râ¯=â¯0.57; pâ¯<â¯0.01) and ADM levels correlated with CFR (râ¯=â¯0.50; pâ¯=â¯0.04) and cFMD (râ¯=â¯0.62; pâ¯=â¯0.01). After adjustment for age, gender and cardiovascular risk factors, the association between ADM and cFMD (ßâ¯=â¯0.79; pâ¯<â¯0.01) and between ET-1 and IMR (ßâ¯=â¯5.7; pâ¯=â¯0.01) remained significant. IMR was higher, although not statistically significant, in patients with long-term MACE (17.9⯱â¯5.3 vs. 13.1⯱â¯6.0â¯units; pâ¯=â¯0.14). In patients free of MACE, cFMD (9.3⯱â¯7.6 vs. 2.8⯱â¯5.0%; pâ¯=â¯0.01) and plasma ADM levels (7.6⯱â¯5.3 vs. 4.0⯱â¯1.9â¯pmol/L; pâ¯=â¯0.07) were higher.CONCLUSIONS:
Plasma ET-1 and ADM were associated with measures of coronary microvascular and coronary conduit vessel function, respectively. Increased cFMD and elevated plasma ADM were associated with a cardioprotective effect.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
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Angiografia Coronária
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Endotelina-1
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Circulação Coronária
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Adrenomedulina
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article