The theory of interceptor-protector action of DNA binding drugs.
Prog Biophys Mol Biol
; 149: 131-146, 2019 12.
Article
em En
| MEDLINE
| ID: mdl-30991057
ABSTRACT
The review discusses the theory of interceptor-protector action (the IPA theory) as the new self-consistent biophysical theory establishing a quantitative interrelation between parameters measured in independent physico-chemical experiment and in vitro biological experiment for the class of DNA binding drugs. The elements of the theory provide complete algorithm of analysis, which may potentially be applied to any system of DNA targeting aromatic drugs. Such analytical schemes, apart from extension of current scientific knowledge, are important in the context of rational drug design for managing drug's response by changing the physico-chemical parameters of molecular complexation.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores de Droga
/
DNA
/
Hidrocarbonetos Aromáticos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article