Determinants of structural segregation and patterning in the human cortex.

ABSTRACT

This study aimed at uncovering mechanisms that govern the spatio-temporal patterning of the human cortex and its structural variability, and drawing links between fetal brain development and variability in adult brains. A data-driven analytic approach based on structural MR images revealed the following findings: (1) The cortical surface can be subdivided into 13 independent regions ("communities") based on macroscopic features. (2) Thirty centers of low inter-subject variability were found in major sulci on the cortical surface. Their variability showed a strong positive correlation with the known time points at which they appear in fetal development. Centers forming early induce a higher inter-subject regularity in a larger local vicinity, while those forming later result in smaller regions of higher variability. (3) The layout of sulcal and gyral patterns within a community is governed typically by two centers. Depending on the relative variability of each center, communities can be classified into structural sub-types. (4) Sub-types across ipsi-lateral communities are independent, but associated with the sub-type of the same community on the contra-lateral side. Results shown here integrate well with current knowledge about macroscopic, microscopic, and genetic determinants of brain development.