A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection.

Luteijn, Rutger D; van Diemen, Ferdy; Blomen, Vincent A; Boer, Ingrid G J; Manikam Sadasivam, Saravanan; van Kuppevelt, Toin H; Drexler, Ingo; Brummelkamp, Thijn R; Lebbink, Robert Jan; Wiertz, Emmanuel J

Luteijn, Rutger D; van Diemen, Ferdy; Blomen, Vincent A; Boer, Ingrid G J; Manikam Sadasivam, Saravanan; van Kuppevelt, Toin H; Drexler, Ingo; Brummelkamp, Thijn R; Lebbink, Robert Jan; Wiertz, Emmanuel J.

Afiliação

Luteijn RD; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
van Diemen F; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Blomen VA; Netherlands Cancer Institute, Amsterdam, The Netherlands.
Boer IGJ; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Manikam Sadasivam S; Department of Membrane Biochemistry and Biophysics, Utrecht University, Utrecht, The Netherlands.
van Kuppevelt TH; Department of Biochemistry, Radboud University Medical Center, Nijmegen, The Netherlands.
Drexler I; Institute for Virology, Universitätsklinikum Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.
Brummelkamp TR; Netherlands Cancer Institute, Amsterdam, The Netherlands.
Lebbink RJ; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Wiertz EJ; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands ewiertz@umcutrecht.nl.

J Virol ; 93(13)2019 07 01.

Article em En | MEDLINE | ID: mdl-30996093

Assuntos

Haploidia; Heparitina Sulfato/genética; Heparitina Sulfato/isolamento & purificação; Pinocitose/fisiologia; Vaccinia virus/genética; Vaccinia virus/metabolismo; Vacínia/virologia; Proteínas de Transporte Vesicular/metabolismo; Sistemas CRISPR-Cas; Linhagem Celular Tumoral; Vírus da Varíola Bovina/genética; Vírus de DNA; Técnicas de Inativação de Genes; Testes Genéticos; Complexo de Golgi; Células HEK293; Células HeLa; Heparitina Sulfato/metabolismo; Especificidade de Hospedeiro; Interações Hospedeiro-Patógeno; Humanos; Proteínas de Membrana; Monkeypox virus/genética; N-Acetilglucosaminiltransferases; Fosfatidilserinas/metabolismo; Poxviridae/genética; Ligação Viral

Palavras-chave

TMED10; genome-wide screen; heparan sulfate; macropinocytosis; phosphatidylserine; poxvirus; vaccinia virus

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pinocitose / Vacínia / Vaccinia virus / Proteínas de Transporte Vesicular / Haploidia / Heparitina Sulfato Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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