Recipient ABCB1, donor and recipient CYP3A5 genotypes influence tacrolimus pharmacokinetics in liver transplant cases.
Pharmacol Rep
; 71(3): 385-392, 2019 Jun.
Article
em En
| MEDLINE
| ID: mdl-31003147
ABSTRACT
BACKGROUND:
Effective immunosuppression through optimization of trough levels tacrolimus reduces post-transplant mortality rate in liver transplant cases.METHODS:
Meta-analysis was carried out to evaluate how donor/recipient CYP3A5 (n = 678) and recipient ABCB1 (n = 318) genotypes influence tacrolimus pharmacokinetics till one-month of transplantation.RESULTS:
The donor CYP3A5*3/*3 genotype exhibited higher concentration/dose (C/D) ratio of tacrolimus in week 1 (mean difference 65.04, 95% CI 15.30-114.79 ng/ml/mg/kg), week 2 (mean difference 21.7, 95% CI 12.6-30.9 ng/ml/mg/kg) and week 4 (mean difference 43.28, 95% CI 17.09 - 69.49 ng/ml/mg/kg) compared to *1/*1 and *1/*3 genotypes. The recipient CYP3A5 *3/*3 genotype did not showed significant difference in tacrolimus C/D ratio in week 1 compared to other two genotypes. However, week 2 (mean difference 44.16, 95% CI 3.68-84.65 ng/ml/mg/kg) and week 4 (mean difference 43.74, 95% CI 12.50-75.00 ng/ml/mg/kg) availability was higher in *3/*3 mutant recipients. However, the recipient ABCB1 3435 C > T polymorphism has no significant influence on tacrolimus pharmacokinetics till one month of transplant.CONCLUSIONS:
The donor and recipient CYP3A5*3 polymorphism influences tacrolimus pharmacokinetics in the first month post-transplantation, whereas the association with recipient ABCB1 3435 C > T is inconclusive.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tacrolimo
/
Citocromo P-450 CYP3A
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article