Your browser doesn't support javascript.
loading
Final Results of the Prospective FH02 Mammographic Surveillance Study of Women Aged 35-39 at Increased Familial Risk of Breast Cancer.
Evans, D G; Thomas, S; Caunt, J; Burch, A; Brentnall, A R; Roberts, L; Howell, A; Wilson, M; Fox, R; Hillier, S; Sibbering, D M; Moss, S; Wallis, M G; Eccles, D M; Duffy, S.
Afiliação
  • Evans DG; Prevent Breast Cancer Centre, Wythenshawe Hospital Manchester Universities Foundation Trust, Wythenshawe, Manchester M23 9LT, UK.
  • Thomas S; Genomic Medicine, Division of Evolution and Genomic Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester Universities Foundation Trust, St. Mary's Hospital, Oxford Road, Manchester M13 9WL, UK.
  • Caunt J; Manchester Breast Centre, Manchester Cancer Research Centre, University of Manchester, Christie Hospital, Withington, Manchester M20 4BX, UK.
  • Burch A; Breast Test Wales, 18 Cathedral Road, Cardiff CF11 9LJ, UK.
  • Brentnall AR; Breast Test Wales, 18 Cathedral Road, Cardiff CF11 9LJ, UK.
  • Roberts L; Breast Test Wales, 18 Cathedral Road, Cardiff CF11 9LJ, UK.
  • Howell A; Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine' Charterhouse Square, London EC1M 6BQ, UK.
  • Wilson M; Prevent Breast Cancer Centre, Wythenshawe Hospital Manchester Universities Foundation Trust, Wythenshawe, Manchester M23 9LT, UK.
  • Fox R; Prevent Breast Cancer Centre, Wythenshawe Hospital Manchester Universities Foundation Trust, Wythenshawe, Manchester M23 9LT, UK.
  • Hillier S; Manchester Breast Centre, Manchester Cancer Research Centre, University of Manchester, Christie Hospital, Withington, Manchester M20 4BX, UK.
  • Sibbering DM; Breast Screening Unit, Nightingale Centre, Wythenshawe Hospital, Manchester University Foundation Trust, Wythenshawe, Manchester M23 9LT, UK.
  • Moss S; Breast Test Wales, 18 Cathedral Road, Cardiff CF11 9LJ, UK.
  • Wallis MG; Breast Test Wales, 18 Cathedral Road, Cardiff CF11 9LJ, UK.
  • Eccles DM; Breast Unit, Royal Derby Hospital, Derby DE22 3NE, UK.
  • Duffy S; Cambridge Breast Unit, NIHR Cambridge Biomedical Research Unit, Box 97, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK.
EClinicalMedicine ; 7: 39-46, 2019 Jan.
Article em En | MEDLINE | ID: mdl-31008449
ABSTRACT

BACKGROUND:

Many women who are at increased risk of breast cancer due to a mother or sister diagnosed with breast cancer aged under 40 do not currently qualify for surveillance before 40 years of age. There are almost no available data to assess whether mammography screening aged 35-39 years would be effective in this group, in terms of detection of breast cancer at an early stage or cost effective.

METHODS:

A cohort screening study (FH02) with annual mammography was devised for women aged 35-39 to assess the sensitivity and screening performance and potential survival of women with identified tumours.

FINDINGS:

2899 women were recruited from 12/2006-12/2015. These women underwent 12,086 annual screening mammograms and were followed for 13,365.8 years. A total of 55 breast cancers in 54 women occurred during the study period (one bilateral) with 50 cancers (49 women) (15 CIS) adherent to the screening. Eighty percent (28/35) of invasive cancers were ≤ 2 cm and 80% also lymph node negative. Invasive cancers diagnosed in FH02 were significantly smaller than the comparable (POSH-unscreened prospective) study group (45% (131/293) ≤ 2 cm in POSH vs 80% (28/35) in FH02 p < 0.0001), and were less likely to be lymph-node positive (54% (158/290, 3 unknown) in POSH vs 20% (7/35) in FH02 p = 0.0002. Projected and actual survival were also better than POSH. Overall radiation dose was not higher than in an older screened population at mean dose on study per standard sized breast of 1.5 mGy.

INTERPRETATION:

Mammography screening aged 35-39 years detects breast cancer at an early stage and is likely to be as effective in reducing mortality as in women at increased breast cancer risk aged 40-49 years.
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article