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Structures of a highly variable cell-wall anchored protein-encoding the spj gene from ST8/SCCmecIVl community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA/J) isolated from 2003 onwards: An indicator of a strongly invasive pathotype.
Wan, Tsai-Wen; Teng, Lee-Jene; Yamamoto, Tatsuo.
Afiliação
  • Wan TW; Department of Epidemiology, Genomics, and Evolution, International Medical Education and Research Center, Niigata, Japan.
  • Teng LJ; Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan.
  • Yamamoto T; Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan.
Microbiol Immunol ; 63(5): 186-193, 2019 May.
Article em En | MEDLINE | ID: mdl-31009089
The cell wall-anchored protein-encoding spj gene on staphylococcal cassette chromosome mec IVl (SCCmecIVl) was found to vary in size because of its 22- and 86-aa repeat domains. The 22-aa repeats are the more flexible of the two repeats, comprising three 11-aa units, and were classified into three groups with eleven types. The 11/22-aa repeats are longer in individuals with bullous impetigo, shorter in those with invasive disease and were absent in a fatal case, this last one having been rapidly diagnosed by PCR. IS431-flanking pUB110 (bleO, aadD) is present on SCCmecIVl at 90%. The bacterial surface has the spj product and a unique surface layer.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Proteínas de Bactérias / Parede Celular / Infecções Comunitárias Adquiridas / Staphylococcus aureus Resistente à Meticilina Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Proteínas de Bactérias / Parede Celular / Infecções Comunitárias Adquiridas / Staphylococcus aureus Resistente à Meticilina Idioma: En Ano de publicação: 2019 Tipo de documento: Article