Ruthenium-catalyzed ortho-selective CAr-H amination of heteroaryl arenes with di-tert-butyldiaziridinone.
Chem Commun (Camb)
; 55(38): 5487-5490, 2019 May 07.
Article
em En
| MEDLINE
| ID: mdl-31017141
ABSTRACT
Application of an oxidative amination reagent (di-tert-butyldiaziridinone) to the Ru3(CO)12-catalyzed ortho-selective CAr-H amination reaction is described. This strategy shows good functional group compatibility with various phenyl-substituted N-heterocycles, including biologically active substrates, thus providing synthetic potential for this methodology. Mechanistic studies showed that the reaction process involves an octahedral ruthenium species, and the carbon monoxide ligand plays a crucial role in the C-H activation.
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MEDLINE
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En
Ano de publicação:
2019
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Article