Genetic diversity of chemokine XCL1 and its receptor XCR1 in murine rodents.
Dev Comp Immunol
; 98: 80-88, 2019 09.
Article
em En
| MEDLINE
| ID: mdl-31026469
ABSTRACT
The chemokine ligand XCL1 plays critical roles in immune responses with diverse physiological and pathological implications through interactions with a cognate G protein-coupled receptor XCR1. To shed insight into their versatile nature, we analyzed genetic variations of XCL1 and XCR1 in murine rodents, including commonly-used model organisms Mus musculus (house mouse) and Rattus norvegicus (Norway rat). Our results showed that adaptive selection has contributed to the genetic diversification of these proteins in murine lineage. Moreover, in both M. musculus and R. norvegicus, the chemokine and its receptor exhibit similar signs of selective sweeps resulting from positive selection. In light of currently available structural and interaction information for chemokines and their receptors, the similarity of XCL1/XCR1 evolutionary patterns among murine species and the parallels of their evolutionary footprints within individual species suggest that interplay could exist between the adaptively selected changes, or between the domains on which the identified changes are located, and consequently preserve the physiological interaction of XCL1 and XCR1.
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Base de dados:
MEDLINE
Assunto principal:
Seleção Genética
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Variação Genética
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Adaptação Fisiológica
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Evolução Molecular
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Receptores de Quimiocinas
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Quimiocinas C
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article