Co-localization of Coagulation Factor X and its Inhibitory System, PZ/ZPI, in Human Endometrial Cancer Tissue.
In Vivo
; 33(3): 771-776, 2019.
Article
em En
| MEDLINE
| ID: mdl-31028196
ABSTRACT
BACKGROUND/AIM:
Hemostatic system components contribute to cancer progression independently from their roles in hemostasis. It has been shown that protein Z (PZ)/protein Z-dependent protease inhibitor (ZPI) inhibit coagulation factor X (FX). The aim of the study was to analyze the expression of PZ/ZPI in relation to the main coagulation factor - FX in human endometrial cancer tissue. MATERIALS ANDMETHODS:
Immunohistochemical analysis was performed on 21 endometrial cancer specimens employing antibodies against ZPI, PZ and FX.RESULTS:
Endometrial cancer cells showed a strong expression of ZPI and PZ and medium expression of FX. Normal endometrial tissue showed no expression of ZPI, PZ or FX.CONCLUSION:
Strong expression of PZ and ZPI in endometrial cancer cells suggests a role of these proteins in endometrial cancer.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fator X
/
Proteínas Sanguíneas
/
Neoplasias do Endométrio
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article