Antisteatotic and antioxidant activities of Thymbra spicata L. extracts in hepatic and endothelial cells as in vitro models of non-alcoholic fatty liver disease.

Khalil, Mohamad; Khalifeh, Hala; Baldini, Francesca; Salis, Annalisa; Damonte, Gianluca; Daher, Ahmad; Voci, Adriana; Vergani, Laura

Khalil, Mohamad; Khalifeh, Hala; Baldini, Francesca; Salis, Annalisa; Damonte, Gianluca; Daher, Ahmad; Voci, Adriana; Vergani, Laura.

Afiliação

Khalil M; Department of Earth, Environment and Life Sciences (DISTAV), University of Genova, Corso Europa 26, 16132, Genova, Italy; Department of Biology, Laboratory Rammal Rammal (ATAC), Faculty of Sciences, Lebanese University, Hadath Campus, Beirut, Lebanon.
Khalifeh H; Department of Biology, Laboratory Rammal Rammal (ATAC), Faculty of Sciences, Lebanese University, Hadath Campus, Beirut, Lebanon.
Baldini F; Department of Earth, Environment and Life Sciences (DISTAV), University of Genova, Corso Europa 26, 16132, Genova, Italy.
Salis A; Department of Experimental Medicine (DIMES), University of Genova, Viale Benedetto XV 1, 16132, Genova, Italy.
Damonte G; Department of Experimental Medicine (DIMES), University of Genova, Viale Benedetto XV 1, 16132, Genova, Italy; Centre of Excellence for Biomedical Research (CEBR), University of Genova, Viale Benedetto XV 9, 16132, Genova, Italy.
Daher A; Department of Biology, Laboratory Rammal Rammal (ATAC), Faculty of Sciences, Lebanese University, Hadath Campus, Beirut, Lebanon.
Voci A; Department of Earth, Environment and Life Sciences (DISTAV), University of Genova, Corso Europa 26, 16132, Genova, Italy.
Vergani L; Department of Earth, Environment and Life Sciences (DISTAV), University of Genova, Corso Europa 26, 16132, Genova, Italy. Electronic address: laura.vergani@unige.it.

J Ethnopharmacol ; 239: 111919, 2019 Jul 15.

Article em En | MEDLINE | ID: mdl-31029756

Assuntos

Antioxidantes/farmacologia; Células Endoteliais/efeitos dos fármacos; Lamiaceae; Hepatopatia Gordurosa não Alcoólica/tratamento farmacológico; Extratos Vegetais/farmacologia; Animais; Movimento Celular/efeitos dos fármacos; Células Cultivadas; Células Endoteliais/fisiologia; Humanos; Metabolismo dos Lipídeos/efeitos dos fármacos; Óxido Nítrico/metabolismo; Estresse Oxidativo/efeitos dos fármacos; Componentes Aéreos da Planta; Ratos; Fator de Transcrição RelA/metabolismo; Cicatrização/efeitos dos fármacos

Palavras-chave

Non-alcoholic fatty liver disease; Oxidative stress; Phenolic compounds; Steatosis; Thymbra spicata

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Lamiaceae / Células Endoteliais / Hepatopatia Gordurosa não Alcoólica / Antioxidantes Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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