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TGF-ß2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism.
Takahashi, Hirokazu; Alves, Christiano R R; Stanford, Kristin I; Middelbeek, Roeland J W; Nigro, Pasquale; Ryan, Rebecca E; Xue, Ruidan; Sakaguchi, Masaji; Lynes, Matthew D; So, Kawai; Mul, Joram D; Lee, Min-Young; Balan, Estelle; Pan, Hui; Dreyfuss, Jonathan M; Hirshman, Michael F; Azhar, Mohamad; Hannukainen, Jarna C; Nuutila, Pirjo; Kalliokoski, Kari K; Nielsen, Søren; Pedersen, Bente K; Kahn, C Ronald; Tseng, Yu-Hua; Goodyear, Laurie J.
Afiliação
  • Takahashi H; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Alves CRR; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Stanford KI; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Middelbeek RJW; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Nigro P; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Ryan RE; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Xue R; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Sakaguchi M; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Lynes MD; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • So K; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Mul JD; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Lee MY; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Balan E; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Pan H; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Dreyfuss JM; Bioinformatics Core, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Hirshman MF; Bioinformatics Core, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Azhar M; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Hannukainen JC; Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, USA.
  • Nuutila P; Turku PET Centre, University of Turku, Turku, Finland.
  • Kalliokoski KK; Turku PET Centre, University of Turku, Turku, Finland.
  • Nielsen S; Turku PET Centre, University of Turku, Turku, Finland.
  • Pedersen BK; The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Kahn CR; The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Tseng YH; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Goodyear LJ; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Nat Metab ; 1(2): 291-303, 2019 02.
Article em En | MEDLINE | ID: mdl-31032475
ABSTRACT
Exercise improves health and well-being across diverse organ systems, and elucidating mechanisms underlying the beneficial effects of exercise can lead to new therapies. Here, we show that transforming growth factor-ß2 (TGF-ß2) is secreted from adipose tissue in response to exercise and improves glucose tolerance in mice. We identify TGF-ß2 as an exercise-induced adipokine in a gene expression analysis of human subcutaneous adipose tissue biopsies after exercise training. In mice, exercise training increases TGF-ß2 in scWAT, serum, and its secretion from fat explants. Transplanting scWAT from exercise-trained wild type mice, but not from adipose tissue-specific Tgfb2-/- mice, into sedentary mice improves glucose tolerance. TGF-ß2 treatment reverses the detrimental metabolic effects of high fat feeding in mice. Lactate, a metabolite released from muscle during exercise, stimulates TGF-ß2 expression in human adipocytes. Administration of the lactate-lowering agent dichloroacetate during exercise training in mice decreases circulating TGF-ß2 levels and reduces exercise-stimulated improvements in glucose tolerance. Thus, exercise training improves systemic metabolism through inter-organ communication with fat via a lactate-TGF-ß2-signaling cycle.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Fator de Crescimento Transformador beta2 / Adipocinas / Ácidos Graxos / Glucose Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Fator de Crescimento Transformador beta2 / Adipocinas / Ácidos Graxos / Glucose Idioma: En Ano de publicação: 2019 Tipo de documento: Article