The E3 ubiquitin ligase, NEDD4L (NEDD4-2) regulates bestrophin-1 (BEST1) by ubiquitin-dependent proteolysis.

Park, Myeongki; Jung, Hyun-Gug; Kweon, Hae-Jin; Kim, Yeong-Eun; Park, Jae-Yong; Hwang, Eun Mi

Park, Myeongki; Jung, Hyun-Gug; Kweon, Hae-Jin; Kim, Yeong-Eun; Park, Jae-Yong; Hwang, Eun Mi.

Afiliação

Park M; Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Neuroscience Program, University of Science and Technology (UST), Daejeon, 305-350, Republic of Korea.
Jung HG; Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul, 02841, Republic of Korea.
Kweon HJ; Neuroscience Discovery, Janssen Pharmaceutical Companies of Johnson & Johnson, 3210 Merryfield Row, San Diego, CA, 92121, USA.
Kim YE; Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Neuroscience Program, University of Science and Technology (UST), Daejeon, 305-350, Republic of Korea.
Park JY; School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul, 02841, Republic of Korea. Electronic address: jaeyong68@korea.ac.kr.
Hwang EM; Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Neuroscience Program, University of Science and Technology (UST), Daejeon, 305-350, Republic of Korea. Electronic address: emhwang@kist.re.kr.

Biochem Biophys Res Commun ; 514(1): 344-350, 2019 06 18.

Article em En | MEDLINE | ID: mdl-31036321

Assuntos

Bestrofinas/metabolismo; Ubiquitina-Proteína Ligases Nedd4/metabolismo; Animais; Bestrofinas/genética; Células HEK293; Humanos; Lisina/metabolismo; Camundongos; Ubiquitina-Proteína Ligases Nedd4/genética; Complexo de Endopeptidases do Proteassoma/metabolismo; Domínios Proteicos; Domínios e Motivos de Interação entre Proteínas; Ubiquitinação; Ubiquitinas/metabolismo

Palavras-chave

BEST1; Chloride channel; E3 ubiquitin ligase; NEDD4L

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ubiquitina-Proteína Ligases Nedd4 / Bestrofinas Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ubiquitina-Proteína Ligases Nedd4 / Bestrofinas Idioma: En Ano de publicação: 2019 Tipo de documento: Article