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Inhibition of the IGF-1-PI3K-Akt-mTORC2 pathway in lipid rafts increases neuronal vulnerability in a genetic lysosomal glycosphingolipidosis.
Sural-Fehr, Tuba; Singh, Harinder; Cantuti-Catelvetri, Ludovico; Zhu, Hongling; Marshall, Michael S; Rebiai, Rima; Jastrzebski, Martin J; Givogri, Maria I; Rasenick, Mark M; Bongarzone, Ernesto R.
Afiliação
  • Sural-Fehr T; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA tuba@alumni.harvard.edu ebongarz@uic.edu.
  • Singh H; Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA.
  • Cantuti-Catelvetri L; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.
  • Zhu H; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.
  • Marshall MS; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.
  • Rebiai R; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.
  • Jastrzebski MJ; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.
  • Givogri MI; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.
  • Rasenick MM; Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA.
  • Bongarzone ER; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA tuba@alumni.harvard.edu ebongarz@uic.edu.
Dis Model Mech ; 12(5)2019 05 23.
Article em En | MEDLINE | ID: mdl-31036560
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Crescimento Insulin-Like I / Esfingolipidoses / Fosfatidilinositol 3-Quinases / Microdomínios da Membrana / Proteínas Proto-Oncogênicas c-akt / Alvo Mecanístico do Complexo 2 de Rapamicina / Lisossomos / Neurônios Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Crescimento Insulin-Like I / Esfingolipidoses / Fosfatidilinositol 3-Quinases / Microdomínios da Membrana / Proteínas Proto-Oncogênicas c-akt / Alvo Mecanístico do Complexo 2 de Rapamicina / Lisossomos / Neurônios Idioma: En Ano de publicação: 2019 Tipo de documento: Article