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Soluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infection.
Zilber, Eva; Martin, Genevieve E; Willberg, Christian B; Fox, Julie; Nwokolo, Nneka; Fidler, Sarah; Frater, John.
Afiliação
  • Zilber E; Nuffield Department of Medicine, University of Oxford.
  • Martin GE; Eva Zilber and Genevieve E. Martin contributed equally to the article.
  • Willberg CB; Nuffield Department of Medicine, University of Oxford.
  • Fox J; Eva Zilber and Genevieve E. Martin contributed equally to the article.
  • Nwokolo N; Nuffield Department of Medicine, University of Oxford.
  • Fidler S; National Institute of Health Research Biomedical Research Centre, Oxford.
  • Frater J; Department of Genitourinary Medicine and Infectious Disease, Guys and St Thomas' NHS Trust.
AIDS ; 33(7): 1253-1256, 2019 06 01.
Article em En | MEDLINE | ID: mdl-31045943
: Soluble forms of the coinhibitory receptors programmed death 1 (PD-1) and Tim-3 exist, but their relationship with T-cell surface expression remains unclear. When measured by an enzyme-linked immunosorbent assay in plasma, soluble PD-1, and soluble Tim-3 were elevated during primary HIV infection, decreased on antiretroviral therapy to levels found in controls, and correlated with cell surface expression. We conclude that soluble PD-1 and soluble Tim-3 are easy to measure biomarkers of immune exhaustion which potentially eliminate the need for flow cytometry.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasma / Infecções por HIV / Linfócitos T CD8-Positivos / Receptor de Morte Celular Programada 1 / Receptor Celular 2 do Vírus da Hepatite A Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasma / Infecções por HIV / Linfócitos T CD8-Positivos / Receptor de Morte Celular Programada 1 / Receptor Celular 2 do Vírus da Hepatite A Idioma: En Ano de publicação: 2019 Tipo de documento: Article