The Relationship between the HLA-G Polymorphism and sHLA-G Levels in Parental Pairs with High-Risk Pregnancy.
Int J Environ Res Public Health
; 16(9)2019 05 01.
Article
em En
| MEDLINE
| ID: mdl-31052398
ABSTRACT
Human leukocyte antigen G (HLA-G) is observed in immune system cells and other organs. It is a class Ib molecule, which plays a pivotal role in the implantation and maintenance of pregnancy. The aim of this study was to assess the relationship between serum sHLA-G levels and the HLA-G allele in parental pairs with complicated obstetric histories. The clinical material consisted of 210 women and 190 men with the experience of a complicated or an unsuccessful pregnancy. The control group included parents-89 women and 86 men-lacking complicated obstetric histories. We applied genetic analysis methods:
isolation of genomic DNA, sequencing, and determination of serum sHLA-G levels. There were no statistically significant differences in the frequencies of the HLA-G -725 C>G polymorphism between particular experimental groups compared with the control group (p > 0.05). The median sHLA-G levels in the women with the HLA-G10101 allele (15.4 U/mL) were significantly higher than in the women with other alleles (p < 0.05). The HLA-G 10101 allele seems to protect against antiphospholipid syndrome, which may be associated with increased serum sHLA-G levels in its carriers. The relationship between serum sHLA-G levels and the HLA-G polymorphisms in the Polish population requires further investigation.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Pais
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Polimorfismo Genético
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Gravidez de Alto Risco
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Antígenos HLA-G
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article