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HBx-related long non-coding RNA 01152 promotes cell proliferation and survival by IL-23 in hepatocellular carcinoma.
Chen, Tianshi; Pei, Jinxian; Wang, Jinjiang; Luo, Ruili; Liu, Lina; Wang, Ling; Jia, Hao.
Afiliação
  • Chen T; Department of infectious diseases, Shanxi provincial people's hospital, Taiyuan 030012, China.
  • Pei J; Department of infectious diseases, Shanxi provincial people's hospital, Taiyuan 030012, China.
  • Wang J; Department of infectious diseases, Shanxi provincial people's hospital, Taiyuan 030012, China.
  • Luo R; Department of infectious diseases, Shanxi provincial people's hospital, Taiyuan 030012, China.
  • Liu L; Shanghai Basilica clinic, 88 Caoxi North Road, Shanghai 200030, China. Electronic address: linaliu98@163.com.
  • Wang L; Shanghai Basilica clinic, 88 Caoxi North Road, Shanghai 200030, China. Electronic address: 247943168@qq.com.
  • Jia H; Faculty of Basic Medicine, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China. Electronic address: fonney@sjtu.edu.cn.
Biomed Pharmacother ; 115: 108877, 2019 Jul.
Article em En | MEDLINE | ID: mdl-31054511
Accumulating evidence suggests that long-noncoding RNA (lncRNA) plays important roles in hepatitis B virus (HBV) infections. However, the mechanism underlying how lncRNA regulate hepatocellular carcinoma process remains largely unknown. In this study we found that the expression of LINC01152 was significantly increased in HBV positive HCC tissues and cells and was induced by HBx in vitro. The overexpression of LINC01152 could increases HCC cell proliferation and promotes tumor formation in nude mice. Mechanistically, HBx could increase the transcription of LINC01152. Elevated LINC01152 binds to the promoter region of IL-23, promoting its transcriptional activity and upregulating the levels of Stat3 and p-Stat3. Our findings suggest that LINC01152 plays an important role in HBV-related hepatocellular carcinoma development and may serve as a therapeutic marker for hepatocellular carcinoma.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transativadores / Carcinoma Hepatocelular / Interleucina-23 / RNA Longo não Codificante / Neoplasias Hepáticas Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transativadores / Carcinoma Hepatocelular / Interleucina-23 / RNA Longo não Codificante / Neoplasias Hepáticas Idioma: En Ano de publicação: 2019 Tipo de documento: Article