Disease severity and blood cytokine concentrations in dogs with natural Babesia rossi infection.
Parasite Immunol
; 41(7): e12630, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-31063593
ABSTRACT
AIMS:
Babesia rossi causes severe disease in dogs. Here, we describe the association between serum cytokine concentrations and disease severity.METHODS:
Seventeen controls and 55 PCR confirmed B rossi-infected dogs were included. Diseased dogs were subdivided into 23 critically ill and 32 relatively well cases. Serum concentrations of 11 cytokines and biochemical markers of disease severity were determined.RESULTS:
Significant differences were detected for IL-6, IL-8, IL-10, MCP-1 and TNF-α between the groups. Generally, the more complicated the disease, the more pro-inflammatory the cytokine milieu. IL-8 showed a reverse trend and was negatively correlated with disease severity. IL-6, MCP-1 and TNF-α were also significantly higher in the dogs that died (n = 9) compared to the dogs that survived (n = 46). IL-8 showed the opposite. MCP-1 and TNF-α were negatively correlated with biochemical markers of severity. Glucose was negatively correlated with IL-6. Cortisol, peripheral parasite density and band neutrophil count were positively correlated, whilst thyroid hormone was negatively correlated with IL-6, MCP-1 and TNF-α.CONCLUSIONS:
As in malaria and sepsis, B rossi infection induces a pro-inflammatory cytokine storm that correlates with disease severity and adverse outcome. The multiplicity of cytokines involved argues for redundancy in the system once the disease is established.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Babesia
/
Citocinas
/
Doenças do Cão
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article