LncRNA HOTAIR in Tumor Microenvironment: What Role?
Int J Mol Sci
; 20(9)2019 May 08.
Article
em En
| MEDLINE
| ID: mdl-31072041
ABSTRACT
lncRNAs participate in many cellular processes, including regulation of gene expression at the transcriptional and post-transcriptional levels. In addition, many lncRNAs can contribute to the development of different human diseases including cancer. The tumor microenvironment (TME) plays an important role during tumor growth and metastatic progression, and most of these lncRNAs have a key function in TME intracellular signaling. Among the numerous identified lncRNAs, several experimental evidences have shown the fundamental role of the lncRNA HOTAIR in carcinogenesis, also highlighting its use as a circulating biomarker. In this review we described the contribution of HOTAIR in the TME modulation, highlighting its relation with cellular and non-cellular components during tumor evolution and progression.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Microambiente Tumoral
/
RNA Longo não Codificante
/
Carcinogênese
/
Neoplasias
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article