Annual decline in forced expiratory volume and airway inflammatory cells and mediators in a general population-based sample.
BMC Pulm Med
; 19(1): 90, 2019 May 09.
Article
em En
| MEDLINE
| ID: mdl-31072364
ABSTRACT
BACKGROUND:
Few studies have examined the relationships between sputum inflammatory markers and subsequent annual decline in forced expiratory volume in 1 s (dFEV1). This study investigated whether indices of airway inflammation are predictors of dFEV1 in a general population-based sample.METHODS:
The study, conducted from 2003 to 2005, included 120 healthy Norwegian subjects aged 40 to 70 years old. At baseline, the participants completed a self-administered respiratory questionnaire and underwent a clinical examination that included spirometry, venous blood sampling, and induced sputum examination. From 2015 to 2016, 62 (52%) participants agreed to a follow-up examination that did not include induced sputum examination. Those with a FEV1/forced vital capacity (FVC) ratio < 0.70 underwent a bronchial reversibility test. The levels of cytokines, pro-inflammatory M1 macrophage phenotypes were measured in induced sputum using bead-based multiplex analysis. The associations between cytokine levels and dFEV1 were then analysed.RESULTS:
The mean dFEV1 was 32.9 ml/year (standard deviation 26.3). We found no associations between dFEV1 and the baseline indices of sputum inflammation. Seven participants had irreversible airflow limitation at follow-up. They had lower FEV1 and gas diffusion at baseline compared with the remaining subjects. Moreover, two of these individuals had a positive reversibility test and sputum eosinophilia at baseline.CONCLUSIONS:
In this cohort of presumably healthy subjects, we found no associations between sputum inflammatory cells or mediators and dFEV1 during 10 years of follow-up.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Escarro
/
Capacidade Vital
/
Volume Expiratório Forçado
/
Pulmão
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article