Atypical complement receptor C5aR2 transports C5a to initiate neutrophil adhesion and inflammation.
Sci Immunol
; 4(35)2019 05 10.
Article
em En
| MEDLINE
| ID: mdl-31076525
ABSTRACT
Chemoattractant-induced arrest of circulating leukocytes and their subsequent diapedesis is a fundamental component of inflammation. However, how tissue-derived chemoattractants are transported into the blood vessel lumen to induce leukocyte entry into tissue is not well understood. Here, intravital microscopy in live mice has shown that the "atypical" complement C5a receptor 2 (C5aR2) and the atypical chemokine receptor 1 (ACKR1) expressed on endothelial cells were required for the transport of C5a and CXCR2 chemokine ligands, respectively, into the vessel lumen in a murine model of immune complex-induced arthritis. Transported C5a was required to initiate C5aR1-mediated neutrophil arrest, whereas transported chemokines were required to initiate CXCR2-dependent neutrophil transdendothelial migration. These findings provide new insights into how atypical chemoattractant receptors collaborate with "classical" signaling chemoattractant receptors to control distinct steps in the recruitment of neutrophils into tissue sites of inflammation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Artrite
/
Complemento C5a
/
Adesão Celular
/
Receptor da Anafilatoxina C5a
/
Neutrófilos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article