Co-delivery of TRAIL and siHSP70 using hierarchically modular assembly formulations achieves enhanced TRAIL-resistant cancer therapy.

Zhou, Anwei; Du, Junjie; Jiao, Mengying; Xie, Daping; Wang, Qianqian; Xue, Lingjing; Ju, Caoyun; Hua, Zichun; Zhang, Can

Zhou, Anwei; Du, Junjie; Jiao, Mengying; Xie, Daping; Wang, Qianqian; Xue, Lingjing; Ju, Caoyun; Hua, Zichun; Zhang, Can.

Afiliação

Zhou A; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 210009, China.
Du J; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 210009, China.
Jiao M; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 210009, China.
Xie D; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 210009, China.
Wang Q; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 210009, China.
Xue L; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 210009, China.
Ju C; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 210009, China. Electronic address: jucaoyun@cpu.edu.cn.
Hua Z; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Zhang C; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 210009, China. Electronic address: zhangcan@cpu.edu.cn.

J Control Release ; 304: 111-124, 2019 06 28.

Article em En | MEDLINE | ID: mdl-31078569

Assuntos

Proteínas de Choque Térmico HSP70/genética; Neoplasias Pulmonares/tratamento farmacológico; RNA Interferente Pequeno/administração & dosagem; Ligante Indutor de Apoptose Relacionado a TNF/administração & dosagem; Células A549; Animais; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/genética; Neoplasias da Mama/patologia; Linhagem Celular Tumoral; Feminino; Humanos; Hialuronoglucosaminidase/metabolismo; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patologia; Masculino; Metaloproteinase 2 da Matriz/metabolismo; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Ligante Indutor de Apoptose Relacionado a TNF/farmacologia; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Biopharmaceuticals; Dual-site targeting; Hierarchically modular assembly; Synergistic cancer therapy; Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL); siHSP70

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Choque Térmico HSP70 / RNA Interferente Pequeno / Ligante Indutor de Apoptose Relacionado a TNF / Neoplasias Pulmonares Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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