Firefighting Induces Acute Inflammatory Responses that are not Relieved by Aspirin in Older Firefighters.
J Occup Environ Med
; 61(7): 617-622, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-31090673
ABSTRACT
OBJECTIVE:
Sudden cardiac events account for 40% to 50% of firefighter line-of-duty deaths. Inflammatory proteins are strong biomarkers of cardiovascular inflammation. The present study investigated the effects of aspirin supplementation on inflammatory biomarkers following firefighting.METHODS:
Using a randomized, placebo-controlled, double-blind crossover design, 24 male firefighters (48.2â±â5.9 years) were allocated into four conditions acute (81âmg; single-dose) aspirin and placebo supplementation, and chronic (81âmg; 14 days) aspirin and placebo supplementation. Inflammatory proteins [interleukin (IL)-6, C-reactive protein (CRP), intracellular adhesion molecule (ICAM)-1, P-selectin, matrix metalloproteinase-9 (MMP-9)] and antioxidant potential [total antioxidant capacity (TAC)] were measured pre- and post-structural firefighting drills.RESULTS:
Firefighting activities significantly increased IL-6, MMP-9, and P-Selectin; however, no changes in TAC and ICAM-1 were detected. Neither acute nor chronic aspirin supplementation attenuated this inflammatory response.CONCLUSION:
Firefighting significantly increases inflammatory biomarkers and neither acute nor chronic low-dose aspirin mitigates this response.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Anti-Inflamatórios não Esteroides
/
Aspirina
/
Exposição Ocupacional
/
Bombeiros
/
Inflamação
/
Doenças Profissionais
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article