Fatal nosocomial hemorrhagic enterocolitis probably caused by adenovirus. Report of one case.
Rev Med Chil
; 147(2): 256-260, 2019 Feb.
Article
em En
| MEDLINE
| ID: mdl-31095177
ABSTRACT
Adenovirus (ADV) is a recognized cause of severe disease among immunocompromised patients. We report a previously healthy 39-year-old female, admitted with influenza pneumonia and evolving with lung hemorrhage and acute renal failure requiring mechanical ventilation and hemodialysis. She received high corticosteroid doses due to an initial suspicion of alveolar hemorrhage. Lymphopenia already present before steroid use (567/µL), was maintained during the whole hospital stay (mean 782/µL). From the second week of admission she presented a high-volume diarrhea (mean 2.5 L/day) associated to intermittent bloody stools. An ulcerative enterocolitis was confirmed by CT images and colonoscopy. ADV was detected in a colonic tissue sample by real time PCR but not by a commercial filmarray test. Cidofovir-probenecid and racecadotril therapy were indicated without changing the clinical course of diarrhea and the patient finally died.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Infecção Hospitalar
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Hospedeiro Imunocomprometido
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Infecções por Adenoviridae
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Enterocolite
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Hemorragia Gastrointestinal
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article