Inhibiting BRAF Oncogene-Mediated Radioresistance Effectively Radiosensitizes BRAF<sup>V600E</sup>-Mutant Thyroid Cancer Cells by Constraining DNA Double-Strand Break Repair.

Robb, Ryan; Yang, Linlin; Shen, Changxian; Wolfe, Adam R; Webb, Amy; Zhang, Xiaoli; Vedaie, Marall; Saji, Motoyasu; Jhiang, Sissy; Ringel, Matthew D; Williams, Terence M

Inhibiting BRAF Oncogene-Mediated Radioresistance Effectively Radiosensitizes BRAF^V600E-Mutant Thyroid Cancer Cells by Constraining DNA Double-Strand Break Repair.

Robb, Ryan; Yang, Linlin; Shen, Changxian; Wolfe, Adam R; Webb, Amy; Zhang, Xiaoli; Vedaie, Marall; Saji, Motoyasu; Jhiang, Sissy; Ringel, Matthew D; Williams, Terence M.

Afiliação

Robb R; Arthur G. James Comprehensive Cancer Center and Richard J. Solove Research Institute, The Ohio State University Medical Center, Columbus, Ohio.
Yang L; Arthur G. James Comprehensive Cancer Center and Richard J. Solove Research Institute, The Ohio State University Medical Center, Columbus, Ohio.
Shen C; Arthur G. James Comprehensive Cancer Center and Richard J. Solove Research Institute, The Ohio State University Medical Center, Columbus, Ohio.
Wolfe AR; Arthur G. James Comprehensive Cancer Center and Richard J. Solove Research Institute, The Ohio State University Medical Center, Columbus, Ohio.
Webb A; Arthur G. James Comprehensive Cancer Center and Richard J. Solove Research Institute, The Ohio State University Medical Center, Columbus, Ohio.
Zhang X; Arthur G. James Comprehensive Cancer Center and Richard J. Solove Research Institute, The Ohio State University Medical Center, Columbus, Ohio.
Vedaie M; Arthur G. James Comprehensive Cancer Center and Richard J. Solove Research Institute, The Ohio State University Medical Center, Columbus, Ohio.
Saji M; Arthur G. James Comprehensive Cancer Center and Richard J. Solove Research Institute, The Ohio State University Medical Center, Columbus, Ohio.
Jhiang S; Arthur G. James Comprehensive Cancer Center and Richard J. Solove Research Institute, The Ohio State University Medical Center, Columbus, Ohio.
Ringel MD; Arthur G. James Comprehensive Cancer Center and Richard J. Solove Research Institute, The Ohio State University Medical Center, Columbus, Ohio.
Williams TM; Arthur G. James Comprehensive Cancer Center and Richard J. Solove Research Institute, The Ohio State University Medical Center, Columbus, Ohio. terence.williams@osumc.edu.

Clin Cancer Res ; 25(15): 4749-4760, 2019 08 01.

Article em En | MEDLINE | ID: mdl-31097454

Assuntos

Quebras de DNA de Cadeia Dupla/efeitos da radiação; Proteínas Proto-Oncogênicas B-raf/antagonistas & inibidores; Proteínas Proto-Oncogênicas B-raf/genética; Tolerância a Radiação/efeitos dos fármacos; Radiossensibilizantes/farmacologia; Neoplasias da Glândula Tireoide/radioterapia; Vemurafenib/farmacologia; Animais; Linhagem Celular Tumoral; Sobrevivência Celular; Reparo do DNA; Humanos; Sistema de Sinalização das MAP Quinases; Masculino; Camundongos; Camundongos Nus; Inibidores de Proteínas Quinases/farmacologia; Tolerância a Radiação/genética; Radioterapia/métodos; Neoplasias da Glândula Tireoide/tratamento farmacológico; Neoplasias da Glândula Tireoide/genética; Neoplasias da Glândula Tireoide/patologia; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Radiossensibilizantes / Tolerância a Radiação / Neoplasias da Glândula Tireoide / Proteínas Proto-Oncogênicas B-raf / Quebras de DNA de Cadeia Dupla / Vemurafenib Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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