Low-risk gestational trophoblastic neoplasia outcome after treatment with VMP regimen from 2005 to 2017.
Taiwan J Obstet Gynecol
; 58(3): 332-337, 2019 May.
Article
em En
| MEDLINE
| ID: mdl-31122520
ABSTRACT
OBJECTIVE:
To evaluate the efficacy and toxicity of VMP regimen applied to the patients with low-risk gestational trophoblastic neoplasia (LR-GTN) treated in Anhui provincial hospital. MATERIALS ANDMETHODS:
Between 2005 and 2017, 87 patients with low-risk gestational trophoblastic neoplasia received VMP regimen, consisted of vincristine (VCR), methotrexate (MTX) and platinum (cisplatin, carboplatin or nedaplatin), 68 of whom received VMP as their first-line chemotherapy, and 19 methotrexate-failed patients received VMP regimen as their second-line chemotherapy. The staging and scoring system was based on International Federation of Gynecology and Obstetrics (FIGO 2000) criteria. We describe and analyze their baseline characteristics, remission/resistance/recurrence rates, adverse reactions and prognosis.RESULTS:
The first-line VMP protocol can achieve an 83.8% remission rate and it tended to develop resistance when the pretreatment ß-hCG reaches 7503.5 IU/L, and can achieve complete remission with FAV and EMA-CO as the salvage regimen. Among the 19 methotrexate-failed patients, 2 of whom were yet resistant to VMP regimen, followed by several courses of salvage chemotherapy such as FAV and EMP, and achieved 89.5% remission rate in second-line VMP group. Resistance to this regimen was obviously related with higher pre-treatment HCG whether used as primary or salvage treatment. Severe myelosuppression (grade 3 or 4) was shown in 4 (5.9%) of 68 cases, of which none was grade 4.CONCLUSION:
For patients diagnosed with LR-GTN VMP regimen was a safe and effective treatment with a high rate of remission.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Indução de Remissão
/
Protocolos de Quimioterapia Combinada Antineoplásica
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Doença Trofoblástica Gestacional
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Antineoplásicos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article