Selective Asymmetric Hydrogenation of Four-Membered Exo-α,ß-Unsaturated Cyclobutanones Using RuPHOX-Ru as a Catalyst.
Org Lett
; 21(11): 4331-4335, 2019 Jun 07.
Article
em En
| MEDLINE
| ID: mdl-31124691
ABSTRACT
The selective asymmetric hydrogenation of four-membered exo-α,ß-unsaturated cyclobutanones has been achieved for the first time using RuPHOX-Ru as a catalyst, providing four-membered exo-cyclic chiral allylic alcohols in high yields and with up to 99.9% ee. The reaction could be performed on a gram scale with a relatively low catalyst loading (up to 10000 S/C), and the resulting products can be transformed to several biologically active molecules.
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MEDLINE
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En
Ano de publicação:
2019
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Article