Synthesis of 2-D-L-Tryptophan by Sequential Ir-Catalyzed Reactions.
Tetrahedron
; 75(15): 2261-2264, 2019 Apr 12.
Article
em En
| MEDLINE
| ID: mdl-31130755
ABSTRACT
Herein, we report a practical synthesis of 2-D-L-tryptophan via sequential Ir-catalyzed C-H borylation, and Ir-catalyzed C-2-deborylative deuteration steps. In this synthetic sequence, deprotection of the Boc and methyl ester groups proved challenging, due to replacement of deuterium with hydrogen. However, mild deprotection conditions were developed to avoid this D/H scrambling. Further, 2-D-L-Tryptophan is stable in many buffers used for biological studies.
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MEDLINE
Idioma:
En
Ano de publicação:
2019
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Article