The Repurposed Drug Disulfiram Inhibits Urease and Aldehyde Dehydrogenase and Prevents <i>In Vitro</i> Growth of the Oomycete <i>Pythium insidiosum</i>.

Krajaejun, Theerapong; Lohnoo, Tassanee; Yingyong, Wanta; Rujirawat, Thidarat; Kumsang, Yothin; Jongkhajornpong, Passara; Theerawatanasirikul, Sirin; Kittichotirat, Weerayuth; Reamtong, Onrapak; Yolanda, Hanna

The Repurposed Drug Disulfiram Inhibits Urease and Aldehyde Dehydrogenase and Prevents In Vitro Growth of the Oomycete Pythium insidiosum.

Krajaejun, Theerapong; Lohnoo, Tassanee; Yingyong, Wanta; Rujirawat, Thidarat; Kumsang, Yothin; Jongkhajornpong, Passara; Theerawatanasirikul, Sirin; Kittichotirat, Weerayuth; Reamtong, Onrapak; Yolanda, Hanna.

Afiliação

Krajaejun T; Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand mr_en@hotmail.com.
Lohnoo T; Research Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Yingyong W; Research Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Rujirawat T; Research Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Kumsang Y; Research Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Jongkhajornpong P; Department of Ophthalmology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Theerawatanasirikul S; Department of Anatomy, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand.
Kittichotirat W; Systems Biology and Bioinformatics Research Group, Pilot Plant Development and Training Institute, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.
Reamtong O; Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Yolanda H; School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.

Antimicrob Agents Chemother ; 63(8)2019 08.

Article em En | MEDLINE | ID: mdl-31138572

Assuntos

Inibidores de Acetaldeído Desidrogenases/farmacologia; Aldeído Desidrogenase/antagonistas & inibidores; Dissulfiram/farmacologia; Oomicetos/efeitos dos fármacos; Pythium/efeitos dos fármacos; Urease/antagonistas & inibidores; Animais; Antifúngicos/farmacologia; Humanos; Simulação de Acoplamento Molecular/métodos; Pitiose/tratamento farmacológico; Pitiose/microbiologia

Palavras-chave

Pythium insidiosum; disulfiram; drug repurposing; pythiosis; susceptibility

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oomicetos / Pythium / Urease / Dissulfiram / Aldeído Desidrogenase / Inibidores de Acetaldeído Desidrogenases Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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