Circulating Tumor Cell cluster phenotype allows monitoring response to treatment and predicts survival.
Sci Rep
; 9(1): 7933, 2019 05 28.
Article
em En
| MEDLINE
| ID: mdl-31138856
ABSTRACT
Circulating tumor cells (CTCs) are putative markers of tumor prognosis and may serve to evaluate patient's response to chemotherapy. CTCs are often detected as single cells but infrequently as clusters and are indicative of worse prognosis. In this study, we developed a short-term culture of nucleated blood cells which was applied to blood samples from breast, lung, esophageal and bladder cancer patients. Clusters of different degrees of compactness, classified as very tight, tight and loose were observed across various cancer types. These clusters show variable expression of cytokeratins. Cluster formation from blood samples obtained during the course of chemotherapy was found to be associated with disease progression and shorter overall survival. The short-term cultures offer a robust and highly reliable method for early prediction of treatment response in different cancer types.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Bexiga Urinária
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Neoplasias da Mama
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Neoplasias Esofágicas
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Neoplasias Pulmonares
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Células Neoplásicas Circulantes
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article