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HIV elite control is associated with reduced TRAILshort expression.
Paim, Ana C; Cummins, Nathan W; Natesampillai, Sekar; Garcia-Rivera, Enrique; Kogan, Nicole; Neogi, Ujjwal; Sönnerborg, Anders; Sperk, Maike; Bren, Gary D; Deeks, Steve; Polley, Eric; Badley, Andrew D.
Afiliação
  • Paim AC; Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota.
  • Cummins NW; Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota.
  • Natesampillai S; Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota.
  • Garcia-Rivera E; Nference, Cambridge, Massachusetts, USA.
  • Kogan N; Nference, Cambridge, Massachusetts, USA.
  • Neogi U; Division of Clinical Microbiology, Karolinska Institutet, Stockholm, Sweden.
  • Sönnerborg A; Division of Clinical Microbiology, Karolinska Institutet, Stockholm, Sweden.
  • Sperk M; Division of Clinical Microbiology, Karolinska Institutet, Stockholm, Sweden.
  • Bren GD; Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota.
  • Deeks S; Division of Infectious Diseases, University of California, San Francisco, San Francisco, California.
  • Polley E; Division of Biomedical Statistics and Informatics.
  • Badley AD; Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota.
AIDS ; 33(11): 1757-1763, 2019 09 01.
Article em En | MEDLINE | ID: mdl-31149947
OBJECTIVE: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) dependent apoptosis has been implicated in CD4 T-cell death and immunologic control of HIV-1 infection. We have described a splice variant called TRAILshort, which is a dominant negative ligand that antagonizes TRAIL-induced cell death in the context of HIV-1 infection. HIV-1 elite controllers naturally control viral replication for largely unknown reasons. Since enhanced death of infected cells might be responsible, as might occur in situations of low (or inhibited) TRAILshort, we tested whether there was an association between elite controller status and reduced levels of TRAILshort expression. DESIGN: Cohort study comparing TRAILshort and full length TRAIL expression between HIV-1 elite controllers and viremic progressors from two independent populations. METHODS: TRAILshort and TRAIL gene expression in peripheral blood mononuclear cells (PBMCs) was determined by RNA-seq. TRAILshort and TRAIL protein expression in plasma was determined by antibody bead array and proximity extension assay respectively. RESULTS: HIV-1 elite controllers expressed less TRAILshort transcripts in PBMCs (P = 0.002) and less TRAILshort protein in plasma (P < 0.001) than viremic progressors. CONCLUSION: Reduced TRAILshort expression in PBMCs and plasma is associated with HIV-1 elite controller status.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Viremia / Linfócitos T CD4-Positivos / Infecções por HIV / Ligante Indutor de Apoptose Relacionado a TNF Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Viremia / Linfócitos T CD4-Positivos / Infecções por HIV / Ligante Indutor de Apoptose Relacionado a TNF Idioma: En Ano de publicação: 2019 Tipo de documento: Article