New subtypes of allele-specific epigenetic effects: implications for brain development, function and disease.
Curr Opin Neurobiol
; 59: 69-78, 2019 12.
Article
em En
| MEDLINE
| ID: mdl-31153086
ABSTRACT
Typically, it is assumed that the maternal and paternal alleles for most genes are equally expressed. Known exceptions include canonical imprinted genes, random X-chromosome inactivation, olfactory receptors and clustered protocadherins. Here, we highlight recent studies showing that allele-specific expression is frequent in the genome and involves subtypes of epigenetic allelic effects that differ in terms of heritability, clonality and stability over time. Different forms of epigenetic allele regulation could have different roles in brain development, function, and disease. An emerging area involves understanding allelic effects in a cell-type and developmental stage-specific manner and determining how these effects influence the impact of genetic variants and mutations on the brain. A deeper understanding of epigenetics at the allele and cellular level in the brain could help clarify the mechanisms underlying phenotypic variance.
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1
Base de dados:
MEDLINE
Assunto principal:
Epigênese Genética
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article