Incidence and mortality of brain abscess in Denmark: a nationwide population-based study.
Clin Microbiol Infect
; 26(1): 95-100, 2020 Jan.
Article
em En
| MEDLINE
| ID: mdl-31158518
ABSTRACT
OBJECTIVES:
To examine the incidence and mortality of brain abscesses.METHODS:
We accessed nationwide population-based medical registries to obtain data for patients with first-time brain abscesses in Denmark from 1982 through 2016. Annual age- and sex-standardized incidence rates with 95% confidence intervals were calculated and compared by direct standardization. We used Cox regression to compute mortality rate ratios adjusted for age and year groups, sex and Charlson comorbidity index score.RESULTS:
We identified 1384 patients (37% female). The overall standardized incidence rate of brain abscess was 0.76 per 100â¯000 person-years (95% confidence interval 0.70-0.81). The incidence rates gradually increased from 0.60 during 1982-88 to 0.90 per 100â¯000 person-years during 2010-16, yielding an incidence rate ratio of 1.50 (95% confidence interval 1.26-1.79). This increase in incidence was most pronounced in the proportions of brain abscess patients >40 years of age and those with immuno-compromise. The 1-year mortality declined from 29% during 1982-88 to 20% during 2010-16, yielding an adjusted mortality rate ratio of 0.44 (95% confidence interval 0.31-0.63). Risk factors for death were advanced age, Charlson comorbidity index >0, immuno-compromised status and congenital heart disease.CONCLUSIONS:
The incidence of brain abscess in Denmark is low but increasing, especially in the elderly, along with an increasing proportion of brain abscess patients with immuno-compromise. The prognosis has improved during the last decades, but mortality remains high. Risk factors for death in our study were advanced age, presence of comorbidity, immuno-compromised status and congenital heart disease.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Abscesso Encefálico
/
Sistema de Registros
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article