Proton Oriented-"Smart Depot" for Responsive Release of Ca<sup>2+</sup> to Inhibit Peptide Acylation in PLGA Microspheres.

Liu, Jiwei; Xu, Yan; Wang, Yonglu; Ren, Hao; Meng, Zhengjie; Liu, Kuntang; Liu, Zhe; Huang, He; Li, Xueming

Proton Oriented-"Smart Depot" for Responsive Release of Ca²⁺ to Inhibit Peptide Acylation in PLGA Microspheres.

Liu, Jiwei; Xu, Yan; Wang, Yonglu; Ren, Hao; Meng, Zhengjie; Liu, Kuntang; Liu, Zhe; Huang, He; Li, Xueming.

Afiliação

Liu J; School of Pharmaceutical Science, Nanjing Tech University, No. 30 Puzhu South Road, Nanjing, 211816, China.
Xu Y; School of Pharmaceutical Science, Nanjing Tech University, No. 30 Puzhu South Road, Nanjing, 211816, China.
Wang Y; School of Pharmaceutical Science, Nanjing Tech University, No. 30 Puzhu South Road, Nanjing, 211816, China.
Ren H; School of Pharmaceutical Science, Nanjing Tech University, No. 30 Puzhu South Road, Nanjing, 211816, China.
Meng Z; School of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, No. 30 Puzhu South Road, Nanjing, 211816, China.
Liu K; School of Pharmaceutical Science, Nanjing Tech University, No. 30 Puzhu South Road, Nanjing, 211816, China.
Liu Z; School of Pharmaceutical Science, Nanjing Tech University, No. 30 Puzhu South Road, Nanjing, 211816, China.
Huang H; School of Pharmaceutical Science, Nanjing Tech University, No. 30 Puzhu South Road, Nanjing, 211816, China. huangh@njtech.edu.cn.
Li X; School of Pharmaceutical Science, Nanjing Tech University, No. 30 Puzhu South Road, Nanjing, 211816, China. xuemingli@njtech.edu.cn.

Pharm Res ; 36(8): 119, 2019 Jun 04.

Article em En | MEDLINE | ID: mdl-31165279

Assuntos

Cálcio/química; Microesferas; Peptídeos/química; Copolímero de Ácido Poliláctico e Ácido Poliglicólico/química; Acilação; Adsorção; Fosfatos de Cálcio/química; Cátions Bivalentes; Portadores de Fármacos; Liberação Controlada de Fármacos; Concentração de Íons de Hidrogênio; Cinética; Octreotida/química; Prótons; Solubilidade; Eletricidade Estática; Água/química

Palavras-chave

Ca3(PO4)2; Peptide acylation; high encapsulation; long-term inhibition; smart depot

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Cálcio / Copolímero de Ácido Poliláctico e Ácido Poliglicólico / Microesferas Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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