Dulaglutide-combined basal plus correction insulin therapy contributes to ideal glycemic control in non-critical hospitalized patients.
J Diabetes Investig
; 11(1): 125-131, 2020 Jan.
Article
em En
| MEDLINE
| ID: mdl-31168938
ABSTRACT
AIMS/INTRODUCTION:
We investigated whether dulaglutide (DU)-combined conventional insulin therapy is beneficial for glycemic control in non-critically ill hospitalized patients with type 2 diabetes. MATERIALS ANDMETHODS:
This study was a prospective, randomized controlled pilot study. Participants were randomized to either basal-plus (BP) therapy, where basal insulin and corrective doses of regular insulin were administered before meals, or BP + DU therapy, where BP therapy was combined with DU. Blood glucose (BG) levels before and after every meal were measured for 7 days after assignment to groups. Because we consider the ideal BG during hospitalization to be within 100-180 mg/dL, we defined this range as the hospitalized ideal glucose range (hIGR). We compared the percentage of BG measurements within the hIGR among all BG measurements (%hIGR), mean BG, glucose variability and insulin dose between the two groups.RESULTS:
Of 54 patients, 27 were assigned to the BP group and 27 to the BP + DU group. The %hIGR was significantly higher (44% vs 56%, P < 0.001), and the frequency of BG >240 mg/dL and BG <70 mg/dL was significantly lower in the BP + DU group than in the BP group (both P < 0.001). The mean BG (183 ± 29 vs 162 ± 30 mg/dL, P < 0.05), standard deviation (P < 0.01), coefficient of variation (P < 0.01) and total regular insulin dose (P < 0.05) in the BP + DU group were significantly lower than those in the BP group. No significant side-effects were observed in either group.CONCLUSIONS:
BP + DU therapy reduced the frequency of hyperglycemia and hypoglycemia, and resulted in a lower glucose variability.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Recombinantes de Fusão
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Fragmentos Fc das Imunoglobulinas
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Diabetes Mellitus Tipo 2
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Peptídeos Semelhantes ao Glucagon
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Hospitalização
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Hiperglicemia
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Hipoglicemia
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Hipoglicemiantes
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Insulina
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article