Lessons from a Minimal Genome: What Are the Essential Organizing Principles of a Cell Built from Scratch?
Chembiochem
; 20(20): 2535-2545, 2019 10 15.
Article
em En
| MEDLINE
| ID: mdl-31177625
ABSTRACT
One of the primary challenges facing synthetic biology is reconstituting a living system from its component parts. A particularly difficult landmark is reconstituting a self-organizing system that can undergo autonomous chromosome compaction, segregation, and cell division. Here, we discuss how the syn3.0 minimal genome can inform us of the core self-organizing principles of a living cell and how these self-organizing processes can be built from the bottom up. The review underscores the importance of fundamental biology in rebuilding life from its molecular constituents.
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MEDLINE
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Células Artificiais
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En
Ano de publicação:
2019
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Article