Synthesis of the Tricyclic Picrotoxane Motif by an Oxidative Cascade Cyclization.
Org Lett
; 21(12): 4896-4899, 2019 06 21.
Article
em En
| MEDLINE
| ID: mdl-31188619
ABSTRACT
An oxidative cascade cyclization of ß-keto esters has been developed for the construction of the tricyclic picrotoxane motif in a single step, and DFT calculations suggested a possible cationic cyclization mechanism. This cascade cyclization can be operated on a 20 g scale to obtain a 77% total yield of the tricyclic products, which in turn can be converted to versatile intermediates for further elaboration to picrotoxanes and their structurally related compounds.
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MEDLINE
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En
Ano de publicação:
2019
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Article