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Discovery of Ziresovir as a Potent, Selective, and Orally Bioavailable Respiratory Syncytial Virus Fusion Protein Inhibitor.
Zheng, Xiufang; Gao, Lu; Wang, Lisha; Liang, Chungen; Wang, Baoxia; Liu, Yongfu; Feng, Song; Zhang, Bo; Zhou, Mingwei; Yu, Xin; Xiang, Kunlun; Chen, Li; Guo, Tao; Shen, Hong C; Zou, Gang; Wu, Jim Zhen; Yun, Hongying.
Afiliação
  • Zheng X; Roche Pharma Research and Early Development , Roche Innovation Center Shanghai , Building 5, 720 Cailun Road , Shanghai 201203 , China.
  • Gao L; Roche Pharma Research and Early Development , Roche Innovation Center Shanghai , Building 5, 720 Cailun Road , Shanghai 201203 , China.
  • Wang L; Roche Pharma Research and Early Development , Roche Innovation Center Shanghai , Building 5, 720 Cailun Road , Shanghai 201203 , China.
  • Liang C; Roche Pharma Research and Early Development , Roche Innovation Center Shanghai , Building 5, 720 Cailun Road , Shanghai 201203 , China.
  • Wang B; Roche Pharma Research and Early Development , Roche Innovation Center Shanghai , Building 5, 720 Cailun Road , Shanghai 201203 , China.
  • Liu Y; Roche Pharma Research and Early Development , Roche Innovation Center Shanghai , Building 5, 720 Cailun Road , Shanghai 201203 , China.
  • Feng S; Roche Pharma Research and Early Development , Roche Innovation Center Shanghai , Building 5, 720 Cailun Road , Shanghai 201203 , China.
  • Zhang B; Roche Pharma Research and Early Development , Roche Innovation Center Shanghai , Building 5, 720 Cailun Road , Shanghai 201203 , China.
  • Zhou M; Roche Pharma Research and Early Development , Roche Innovation Center Shanghai , Building 5, 720 Cailun Road , Shanghai 201203 , China.
  • Yu X; Roche Pharma Research and Early Development , Roche Innovation Center Shanghai , Building 5, 720 Cailun Road , Shanghai 201203 , China.
  • Xiang K; Roche Pharma Research and Early Development , Roche Innovation Center Shanghai , Building 5, 720 Cailun Road , Shanghai 201203 , China.
  • Chen L; Roche Pharma Research and Early Development , Roche Innovation Center Shanghai , Building 5, 720 Cailun Road , Shanghai 201203 , China.
  • Guo T; International Discovery Service Unit, Research Service Division , WuXi AppTec (Shanghai) Co., Ltd. , Lane 31, Yiwei Road, Waigaoqiao , Shanghai , 200131 , China.
  • Shen HC; Roche Pharma Research and Early Development , Roche Innovation Center Shanghai , Building 5, 720 Cailun Road , Shanghai 201203 , China.
  • Zou G; Ark Biosciences Inc. , 780 Cailun Road, Suite 701, ZhangJiang Hitech Park, Pudong , Shanghai 201203 , China.
  • Wu JZ; Ark Biosciences Inc. , 780 Cailun Road, Suite 701, ZhangJiang Hitech Park, Pudong , Shanghai 201203 , China.
  • Yun H; Roche Pharma Research and Early Development , Roche Innovation Center Shanghai , Building 5, 720 Cailun Road , Shanghai 201203 , China.
J Med Chem ; 62(13): 6003-6014, 2019 07 11.
Article em En | MEDLINE | ID: mdl-31194544
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Quinazolinas / Tiazepinas / Benzazepinas / Proteínas Virais de Fusão / Vírus Sincicial Respiratório Humano / Infecções por Vírus Respiratório Sincicial Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Quinazolinas / Tiazepinas / Benzazepinas / Proteínas Virais de Fusão / Vírus Sincicial Respiratório Humano / Infecções por Vírus Respiratório Sincicial Idioma: En Ano de publicação: 2019 Tipo de documento: Article